An aging-associated disease is a disease that is most often seen with
increasing frequency with increasing senescence. Essentially,
aging-associated diseases are complications arising from senescence.
Age-associated diseases are to be distinguished from the aging process
itself because all adult animals age, save for a few rare exceptions,
but not all adult animals experience all age-associated diseases.
Aging-associated diseases do not refer to age-specific diseases, such
as the childhood diseases chicken pox and measles. "Aging-associated
disease" is used here to mean "diseases of the elderly". Nor should
aging-associated diseases be confused with accelerated aging diseases,
all of which are genetic disorders.Examples of aging-associated
diseases are atherosclerosis and cardiovascular disease, cancer,
arthritis, cataracts, osteoporosis, type 2 diabetes, hypertension and
Alzheimer's disease. The incidence of all of these diseases increases
exponentially with age.Of the roughly 150,000 people who die each day
across the globe, about two thirdsâ€"100,000 per dayâ€"die of
age-related causes. In industrialized nations, the proportion is
higher, reaching 90%.By age 3 about 30% of rats have had cancer,
whereas by age 85 about 30% of humans have had cancer. Humans, dogs
and rabbits get Alzheimer's disease, but rodents do not. Elderly
rodents typically die of cancer or kidney disease, but not of
cardiovascular disease. In humans, the relative incidence of cancer
increases exponentially with age for most cancers, but levels off or
may even decline by age 60â€"75 (although colon/rectal cancer
continues to increase).
increasing frequency with increasing senescence. Essentially,
aging-associated diseases are complications arising from senescence.
Age-associated diseases are to be distinguished from the aging process
itself because all adult animals age, save for a few rare exceptions,
but not all adult animals experience all age-associated diseases.
Aging-associated diseases do not refer to age-specific diseases, such
as the childhood diseases chicken pox and measles. "Aging-associated
disease" is used here to mean "diseases of the elderly". Nor should
aging-associated diseases be confused with accelerated aging diseases,
all of which are genetic disorders.Examples of aging-associated
diseases are atherosclerosis and cardiovascular disease, cancer,
arthritis, cataracts, osteoporosis, type 2 diabetes, hypertension and
Alzheimer's disease. The incidence of all of these diseases increases
exponentially with age.Of the roughly 150,000 people who die each day
across the globe, about two thirdsâ€"100,000 per dayâ€"die of
age-related causes. In industrialized nations, the proportion is
higher, reaching 90%.By age 3 about 30% of rats have had cancer,
whereas by age 85 about 30% of humans have had cancer. Humans, dogs
and rabbits get Alzheimer's disease, but rodents do not. Elderly
rodents typically die of cancer or kidney disease, but not of
cardiovascular disease. In humans, the relative incidence of cancer
increases exponentially with age for most cancers, but levels off or
may even decline by age 60â€"75 (although colon/rectal cancer
continues to increase).
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