Strategies for Engineered Negligible Senescence (SENS) is the term
coined by British biogerontologist Aubrey de Grey for the diverse
range of regenerative medical therapies, either planned or currently
in development, for the periodical repair of all age-related damage to
human tissue with the ultimate purpose of maintaining a state of
negligible senescence in the patient, thereby postponing
age-associated disease for as long as the therapies are reapplied.The
term "negligible senescence" was first used in the early 1990s by
professor Caleb Finch to describe organisms such as lobsters and
hydras, which do not show symptoms of aging. The term "engineered
negligible senescence" first appeared in print in Aubrey de Grey's
1999 book The Mitochondrial Free Radical Theory of Aging. De Grey
called SENS a "goal-directed rather than curiosity-driven" approach to
the science of aging, and "an effort to expand regenerative medicine
into the territory of aging".While many biogerontologists find it
"worthy of discussion", some contend that the ultimate goals of de
Grey's programme are too speculative given the current state of
technology, referring to it as "fantasy rather than science".The
ultimate objective of SENS is the eventual elimination of age-related
diseases and infirmity by repeatedly reducing the state of senescence
in the organism. The SENS project consists in implementing a series of
periodic medical interventions designed to repair, prevent or render
irrelevant all the types of molecular and cellular damage that cause
age-related pathology and degeneration, in order to avoid debilitation
and death from age-related causes.
coined by British biogerontologist Aubrey de Grey for the diverse
range of regenerative medical therapies, either planned or currently
in development, for the periodical repair of all age-related damage to
human tissue with the ultimate purpose of maintaining a state of
negligible senescence in the patient, thereby postponing
age-associated disease for as long as the therapies are reapplied.The
term "negligible senescence" was first used in the early 1990s by
professor Caleb Finch to describe organisms such as lobsters and
hydras, which do not show symptoms of aging. The term "engineered
negligible senescence" first appeared in print in Aubrey de Grey's
1999 book The Mitochondrial Free Radical Theory of Aging. De Grey
called SENS a "goal-directed rather than curiosity-driven" approach to
the science of aging, and "an effort to expand regenerative medicine
into the territory of aging".While many biogerontologists find it
"worthy of discussion", some contend that the ultimate goals of de
Grey's programme are too speculative given the current state of
technology, referring to it as "fantasy rather than science".The
ultimate objective of SENS is the eventual elimination of age-related
diseases and infirmity by repeatedly reducing the state of senescence
in the organism. The SENS project consists in implementing a series of
periodic medical interventions designed to repair, prevent or render
irrelevant all the types of molecular and cellular damage that cause
age-related pathology and degeneration, in order to avoid debilitation
and death from age-related causes.
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